Growth Curves of SCC Tumor against the Time (days) after Treatments. (Control) group was without any treatments. (5ALA, hυ) group was irradiated 150mW/cm2 for 1,000sec (150 J/cm2) at 635 nm of LD laser 5 hrs after oral administration of 1 M 5-ALA saline (final concentration was 10 mM). (5-ALA/TiO2, hυ) group was irradiated 150mW/cm2 for 1,000sec (150 J/cm2) at 635 nm of LD laser 5 hrs after oral administration of 1 M 5-ALA saline (final concentration was 10 mM) with 20% nanoparticle (the final concentration was 0.2%). (5ALA/TiO2, hυ+ US) group was irradiated 150mW/cm2 for 1,000sec (150 J/cm2) at 635 nm of LD laser and irradiated for 10 min of ultrasound of 1 MHz (Figure 1) 5 hrs after oral administration of 1 M 5-ALA saline (final concentration was 10 mM) with 20% nanoparticle (the final concentration was 0.2%), respectively. The average tumor volume of 5 tumors was plotted on each curve in each groups.