Physicochemical variables of the acid-base metabolic component before and
after hypercapnia initiation. A) SIDai evolution (mixed model fixed
effects p = 0.646 for within-group factor analysis, p = 0.045 for
between-group factor analysis, and p = 0.224 for group × time
interaction analysis). B) Strong ion gap evolution (mixed model fixed
effects p < 0.001 for within-group factor analysis, p < 0.001 for
between-group factor analysis, and p = 0.007 for group × time
interaction analysis). C) Lactate evolution (mixed model fixed effects p
< 0.978 for within-group factor analysis, p < 0.001 for
between-group factor analysis, and p = 0.975 for group × time
interaction analysis). D) Atot evolution (mixed model fixed effects p =
0.141 for within-group factor analysis, p = 0.010 for between-group
factor analysis, and p = 0.266 for group × time interaction
analysis).
SIDai - inorganic apparent strong ion difference; SIG - strong ion gap;
Atot - weak acids in plasma. * Mann-Whitney's post-hoc analysis p <
0.05 versus control group. # Wilcoxon's post-hoc analysis p < 0.05
versus admission day.