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. Author manuscript; available in PMC: 2016 Apr 11.

Published in final edited form as: Neurosci Biobehav Rev. 2015 Aug 10;58:63–78. doi: 10.1016/j.neubiorev.2015.07.011

Table 1.

Summary list of CRF family peptides, splice variants of each receptor subtype, and the affinity of each ligand for receptors.

Receptor	Splice variant	Ligand affinity
Receptor	Splice variant	CRF	Urocortin 1	Urocortin 2	Urocortin 3
CRF₁	CRF_1A (archetype)	High	Equal	Low	Low
	CRF_1B (intracellular domain)
	CRF_1C (N-terminus)
	CRF_1D (transmembrane domain)
	CRF_1E (N-terminus)
	CRF_1F (intracellular domain)
	CRF_1G (transmembrane domain)
	CRF_1H (N-terminus)
CRF₂	CRF_2A (archetype)	Low	Equal	High	High
	CRF_2B (N-terminus)
	CRF_2C (N-terminus)