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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Neurochem. 2016 Feb 25;137(2):142–153. doi: 10.1111/jnc.13551

Figure 2. The epigenetics of epileptogenesis.

Figure 2

Increased ADK expression (top) drives increased DNA methylation as a prerequisite for progressive epileptogenesis and seizure generation. Conversely, adenosine therapy (bottom) restores normal DNA methylation preventing epileptogenesis. ADO: adenosine; ADK: adenosine kinase; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; DNMT: DNA-methyltransferase.