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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Toxicon. 2016 Mar 4;115:55–62. doi: 10.1016/j.toxicon.2016.03.003

Fig. 3. Regulation of HA/protease expression.

Fig. 3

Nutrient limitation results in expression and activation of the RNA polymerase alternative σ subunit S (σS or RpoS) and the cAMP receptor protein (CRP). Nutrient limitation and high population cell density concertedly activate expression of the quorum sensing regulator HapR. HapR and σS activate the transcription of hapA encoding HA/protease which is secreted via the type II secretion system.