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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2015 Dec 15;23(24):7497–7520. doi: 10.1016/j.bmc.2015.10.012

Figure 3.

Figure 3

BLI assessment of vascular disruption caused in MDA-MB-231-luc orthotopic human tumor xenografts by analogue 73. Dynamic BLI was performed at baseline (bottom row), 4 h after VDA administration (middle), and after 24 h (top), and images are shown for representative mice 17 min after administering fresh luciferin substrate on each occasion to each animal. Images show bioluminescent signal intensity overlaid on photographs of the mice. Analogue 73 was administered at 20, 30 or 40 mg/kg IP in saline, and additional mice received saline control or CA4P (120 mg/kg) for comparison. Analogue 73 caused a reduced signal at all doses at 4 h with substantial recovery by 24 h.