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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2015 Dec 15;23(24):7497–7520. doi: 10.1016/j.bmc.2015.10.012

Figure 5.

Figure 5

Dynamic bioluminescence with respect to vascular disruption.

Graphs show evolution of light emission from individual MDA-MB-231-luc tumors following administration of luciferin substrate subcutaneously in the fore-back region of each mouse at baseline (blue) and 4 h after administration of agent (red). Analogue 73 had a modest effect at 30 mg/kg and a greater effect at 40 mg/kg. By comparison control saline showed a high degree of reproducibility and CA4P showed >90% reduction in light emission.