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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Mol Nutr Food Res. 2016 Feb 18;60(4):858–870. doi: 10.1002/mnfr.201500814

Figure 3. Histologic evaluation of livers from Nrf2-null and wild-type mice fed a high-fat diet containing GTE at 0 or 2% for 8 wk.

Figure 3

A) Representative hematoxylin and eosin-stained liver sections (original magnification 200x) in WT and Nrf2-null mice fed a high fat with or without GTE. Nrf2-null mice had exacerbated macrovesicular steatosis and hepatocyte ballooning relative to WT mice. GTE reduced these parameters regardless of genotype, but the effects were more pronounced in WT mice. Histologic scoring of liver steatosis (B), hepatocyte ballooning (C), and inflammatory infiltrates. Data were analyzed by 2-way ANOVA with Newman–Keuls post-test to evaluate main and interactive effects. Groups without a common letter are significantly different (P<0.05). Data are means ± SEM, n = 10-12 mice per group). Abbreviations: GTE, green tea extract; Nrf2, nuclear factor erythroid-2-related factor-2; WT, wild-type.