A) Representative hematoxylin and eosin-stained liver sections (original magnification 200x) in WT and Nrf2-null mice fed a high fat with or without GTE. Nrf2-null mice had exacerbated macrovesicular steatosis and hepatocyte ballooning relative to WT mice. GTE reduced these parameters regardless of genotype, but the effects were more pronounced in WT mice. Histologic scoring of liver steatosis (B), hepatocyte ballooning (C), and inflammatory infiltrates. Data were analyzed by 2-way ANOVA with Newman–Keuls post-test to evaluate main and interactive effects. Groups without a common letter are significantly different (P<0.05). Data are means ± SEM, n = 10-12 mice per group). Abbreviations: GTE, green tea extract; Nrf2, nuclear factor erythroid-2-related factor-2; WT, wild-type.