TUNEL staining was performed on brain sections from mice treated with isotype control, Fc-TWEAK, and unmanipulated B6 mice. Representative TUNEL positive cells from the cortex are shown magnified in the white box in the right upper corner of the image. Quantitation of the number of TUNEL positive cells is shown in the lower panel. For TUNEL staining, the number of mice in the istoype control, Fc-TWEAK, and unmanipulated B6 groups was 11, 12, and 4, respectively.