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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2016 Feb 27;39:61–68. doi: 10.1016/j.ceb.2016.02.010

Table 1.

Protein Residue Kinase Location in structure Functional effect Reference
ULK1 T180 ULK1 autophosphorylation Activation loop in catalytic domain Stimulates ULK1 kinase activity 40
S317 AMPK IDR Stimulates ULK1 kinase activity 22
S467 AMPK IDR Required for mitochondrial homeostasis during starvation 25
S555 AMPK IDR Required for mitochondrial homeostasis during starvation, regulates Atg9 localization 25, 26, 27
T574 AMPK IDR Required for mitochondrial homeostasis during starvation 25
S637 mTORC1 IDR Promotes ULK1-AMPK interaction 26
AMPK Required for mitochondrial homeostasis during starvation, regulates Atg9 localization 25,27
S659 AMPK IDR Regulates Atg9 localization 27
S757 mTORC1 IDR Inhibits ULK1 kinase activity 22, 25, 26
S777 AMPK IDR near N-terminus of EAT domain Stimulates ULK1 kinase activity 22, 25
ATG13 S224 AMPK IDR Inhibits ULK1 kinase activity 23
S258 mTORC1 IDR Inhibits ULK1 kinase activity 23
S389 ULK1 IDR Unknown 37
ATG101 S11 ULK1 HORMA Unknown 37
S203 ULK1 Flexible region just past C-terminus of HORMA Unknown 37
FIP200 S943 ULK1 Coiled coil Unknown 37
S989 ULK1 Coiled coil Unknown 37
S1323 ULK1 Coiled coil Unknown 37