Neonatal phenobarbital, but not retigabine, increases adult anxiety-like behavior in the elevated plus maze.
(A) Mean + SEM time spent in the open arms of the elevated plus maze. (B) Mean + SEM number of entries to the open arms. (C) Mean + SEM total number of arm entries. * indicates significantly different than vehicle (P<0.05). Decreased time in the open arms is consistent with increased anxiety-like behavior.