(D) Brain weight at 21 dpi. (E,F) Serum concentration of TNF-α (E) and IL-10 (F) at 0, 7, 14, and 21 dpi (n=6). Data are presented as mean ± SEM. Statistical analysis, one-way ANOVA with dpi as repeated measurement; * tukey-adjusted multiple comparisons between control and PRRSV piglets at specified time points, P < 0.05. a,b tukey-adjusted multiple comparison across different time points within the treatment, different small letter P < 0.05.