Table 2.
CFU in kidneys of mice treated with antibody
| Treatment groupsa | CFUs in Kidneyb (log10/g of kidney) | pc |
|---|---|---|
| rSap2 | 1.30±0.46 | <0.01 |
| EPSP nanofibers | 1.34±0.54 | <0.05 |
| WTP nanofibers | 2.47±0.55 | NS (not significant) |
| PBS | 2.45±0.46 |
Mice were inoculated with 100 µL PBS containing 2×107 CA cells via an intravenous injection. Four hours later, 6 mice each group were chosen randomly for treatment with the reagents below: (1) 100 µl of purified antibody against rpSap2 at a dose of 5.0 mg/kg mice weight; (2) 100 µl of purified antibody against EPSP at a dose of 5.0 mg/kg mice weight; (3) 100 µl of purified antibody against WTP at a dose of 5.0 mg/kg mice weight; (4) 100 µl PBS at a dose of 5.0 mg/kg mice weight.
Two days after injection of antibodies, kidneys of mice were collected, weighed and homogenized with a glass grinder in sterile physiological saline. CFUs were counted and recorded.
Difference analysis with student’s t-test showed that the EPSP antibody (p<0.05) and rSap2 (p<0.01) antibody greatly decreased the CFU in kidneys of mice against candidiasis compared with the control (PBS) group.