Table 1.

Comparison of phenotypic features of primary SS patients with and without anti-PUF60 antibodies

Phenotypic feature	PUF60 positive (n=25)	PUF60 negative (n=59)	P value*
Age, median (range)	55 (30–78)	57 (20–82)	0.55
Female	24/25 (96)	51/59 (86)	0.1953
Race			0.01
Caucasian	17/25 (68)	55/59 (93)
Asian	3/25 (12)	1/59 (2)
African-American	4/25 (16)	2/59 (3)
Positive Schirmer (<5 mm/5 min)	12/19 (63)	37/44 (84)	0.0742
Positive lip biopsy	8/8 (100)	25/36 (69)	0.1702
WBC<4000/μl	6/25 (24)	8/58 (14)	0.2546
C3<90 mg/dl	4/25 (16)	3/56 (5)	0.1941
C4<16 mg/dl	3/24 (13)	10/56 (18)	0.7445
ANA ≥1:320	22/25 (88)	28/57 (49)	0.0011
Monoclonal protein	2/25 (8)	8/54 (15)	0.3818
Rheumatoid factor positive	23/25 (92)	10/56 (18)	<.0001
IgG>1445 mg/dl	23/25 (92)	18/53 (34)	<.0001
Anti-SSB/La	16/25 (64)	18/59 (31)	0.0042
Anti-Ro52	25/25 (100)	40/59 (68)	0.0005
Anti-Ro60	22/25 (88)	40/59 (68)	0.0623
Anti-Ro52 and/or Ro60	25/25 (100)	48/59 (81)	0.0289
Anti-thyroid antibodies	2/20 (10)	13/29 (45)	0.0121

^*Pearson chi-square unless cell frequency ≤5, in which case Fisher’s exact test used

Continuous variable (age) tested with Wilcoxon rank sum.