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. Author manuscript; available in PMC: 2016 Apr 12.
Published in final edited form as: Biochem J. 2015 Apr 27;469(1):71–82. doi: 10.1042/BJ20141455

Figure 2. Bioinformatic analysis of differentially expressed pathways.

Figure 2

Enriched pathways in HFD compared with chow (A) and HFD + adiponectin compared with HFD (B) data. Pathways are represented by nodes in the network. The size of the nodes directly correlates to the number of metabolites annotated to a pathway. The node colour indicates the direction of metabolite expression causing the significant enrichment, where red is up-regulation, blue is down-regulation and white indicates that there are equal numbers of up- and down-regulated metabolites (or no change). Edges (lines) represent known pathway cross-talk, defined by the number of metabolites shared between a pair of pathways (as calculated using overlap coefficient <0.3). To enable easier comparison between the two enrichment maps, all results were merged, but only the pathways relevant for a particular comparison are highlighted (colours and labels).