Table 1.
Tissue representation of cell lines in large in vitro pharmacogenomics databases
| Malignancy | CCLE | GDSC | CTRP | NCI-60 | Unique |
|---|---|---|---|---|---|
| Bladder | 28 | 18 | 5 | 0 | 29 |
| Bone | 29 | 31 | 1 | 0 | 53 |
| Breast | 60 | 43 | 1 | 5 | 64 |
| Cervix | 0 | 12 | 0 | 0 | 12 |
| Colon | 63 | 35 | 37 | 7 | 70 |
| Endometrium | 28 | 10 | 11 | 0 | 29 |
| Head and neck | 35 | 23 | 2 | 0 | 44 |
| Hematopoietic and lymphoid | 181 | 113 | 24 | 6 | 227 |
| Kidney | 36 | 22 | 2 | 8 | 48 |
| Liver | 36 | 14 | 4 | 0 | 41 |
| Lung | 187 | 141 | 91 | 9 | 226 |
| Nervous system | 86 | 79 | 3 | 6 | 126 |
| Osephagus | 27 | 23 | 3 | 0 | 29 |
| Ovary | 52 | 20 | 26 | 7 | 57 |
| Pancreas | 46 | 17 | 10 | 0 | 47 |
| Prostate | 8 | 5 | 1 | 2 | 9 |
| Skin | 62 | 45 | 9 | 10 | 79 |
| Soft tissue | 21 | 17 | 3 | 0 | 28 |
| Stomach | 38 | 18 | 6 | 0 | 44 |
| Testis | 0 | 2 | 0 | 0 | 2 |
| Thyroid | 12 | 12 | 0 | 0 | 16 |
| Other | 11 | 7 | 3 | 0 | 20 |
| Total # of cell lines | 1,046 | 707 | 242 | 60 | 1300 |
| Total # of agents tested | 24 | 139 | 185 | −50,000 |
NOTE: The number of cell lines across all tissues is listed for each database along with the total number of agents tested. The final column identifies the number of unique cell lines across all four datasets for each cancer type.