Figure 5.

Increasing range of changes in the PMC subregions with altered functional connectivity in the MCI, mAD, and sAD stages. In MCI group, we did not find the overlapped brain areas with significantly different functional connectivity between the analyses with and without global signal regression. For mAD and sAD groups, in both hemispheres, the functional changes began in the PMCvd and then expanded to the surrounding subregions of the PMCvv. Distinct subregions had disrupted connectivity with different brain networks during the AD progression. Interactions between the PMC subregions and the memory, default mode, and visual networks changed gradually.