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. 2016 Jan 6;34:509–520. doi: 10.1007/s40273-015-0366-8
The results indicate that initiation of therapy with sildenafil in patients with functional class (FC) II and III PAH would result in probable cost savings compared with riociguat, bosentan, ambrisentan 5 mg, ambrisentan 10 mg and tadalafil.
The study findings do not support differential funding of PAH therapies for patients with FC II versus FC III disease based on current evidence.