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. 2016 Mar 9;147:847–855. doi: 10.1007/s00706-016-1713-y

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Metabolism of BaP by rat recombinant CYP1A1 in Supersomes™ in the presence of either NADPH or NADH and the effect of cytochrome b ₅ on this metabolism. Beside CYP1A1 and POR over-expressed in Supersomes™, this enzymatic system also contained mEH. Values represent mean ± SD from three parallel measurements. ***P < 0.001 (Student’s t test), significantly different from incubations without cytochrome b ₅; ^ΔΔΔΔP < 0.001 (Student’s t test), significantly different from incubations in the presence of NADPH