Table 2.
Association of metabolites with incident hypertension.
| Class | Metabolite | RT | Fold change | P | OR | P adj |
|---|---|---|---|---|---|---|
| Amino acids and derivatives | Threonine | 21.87 | 0.12 | 1.46 × 10−4 | 0.33 (0.16–0.70) | 1.78 × 10−4 |
| Nicotinoyl glycine | 8.28 | 0.49 | 2.31 × 10−2 | 0.52 (0.28–0.96) | 1.21 × 10−2 | |
| Glycine | 8.58 | 0.36 | 2.71 × 10−2 | 0.78 (0.44–1.38) | 1.31 × 10−1 | |
| Phenylalanine | 13.02 | 0.70 | 3.44 × 10−2 | 0.49 (0.26–0.91) | 1.12 × 10−2 | |
| S-Carboxymethylcysteine | 24.78 | 0.49 | 4.03 × 10−2 | 0.58 (0.32–1.05) | 6.56 × 10−2 | |
| Tyrosine | 16.70 | 0.58 | 4.76 × 10−2 | 0.73 (0.42–1.29) | 3.79 × 10−1 | |
| Aspartic acid | 21.22 | 0.55 | 4.92 × 10−2 | 0.53 (0.28–0.99) | 2.38 × 10−2 | |
| Gly-Pro | 13.38 | 0.40 | 4.99 × 10−2 | 0.71 (0.4–1.23) | 1.02 × 10−2 | |
|
| ||||||
| Carbohydrate | Talose | 16.88 | 10.88 | 1.69 × 10−6 | 11.64 (3.39–39.96) | 9.01 × 10−5 |
| Lyxose | 14.47 | 2.29 | 1.24 × 10−4 | 2.88 (1.44–5.73) | 4.26 × 10−5 | |
| Galactose | 16.49 | 0.22 | 2.81 × 10−4 | 0.34 (0.17–0.7) | 5.71 × 10−4 | |
| Glucose-1-phosphate | 16.41 | 1.04 × 10−6 | 1.06 × 10−3 | 0.34 (0.16–0.71) | 2.40 × 10−3 | |
| Methyl-beta-D-galactopyranoside | 14.32 | 0.37 | 6.73 × 10−3 | 0.28 (0.13–0.6) | 1.20 × 10−3 | |
| Dihydroxyacetone | 7.06 | 0.50 | 3.12 × 10−2 | 0.62 (0.34–1.11) | 9.84 × 10−2 | |
| Melezitose | 23.25 | 0.48 | 3.81 × 10−2 | 0.54 (0.29–1.01) | 8.38 × 10−2 | |
|
| ||||||
| Carboxylic acids and derivatives | Methylmalonic acid | 8.13 | 3.04 | 1.47 × 10−7 | 5.24 (2.1–13.03) | 2.37 × 10−5 |
| Malonic acid | 11.16 | 12.47 | 3.29 × 10−5 | 12.55 (3.4–46.39) | 1.24 × 10−4 | |
| Shikimic acid | 14.33 | 5.56 | 5.85 × 10−3 | 5.06 (2.07–12.33) | 3.00 × 10−4 | |
| Oxalic acid | 6.19 | 0.56 | 3.29 × 10−2 | 0.57 (0.31–1.02) | 7.11 × 10−2 | |
|
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| Phenols and derivatives | Thymol | 14.17 | 0.31 | 4.14 × 10−3 | 0.43 (0.23–0.83) | 6.00 × 10−3 |
| Noradrenaline | 8.45 | 0.49 | 7.05 × 10−3 | 0.46 (0.24–0.87) | 5.49 × 10−3 | |
| 2-Aminophenol | 9.19 | 0.34 | 1.02 × 10−2 | 0.55 (0.29–1.01) | 5.44 × 10−2 | |
|
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| Others | 2-Methoxyestrone | 19.65 | 0.57 | 1.74 × 10−2 | 0.39 (0.2–0.76) | 8.71 × 10−3 |
| Alpha-tocopherol | 27.36 | 0.60 | 3.23 × 10−2 | 0.47 (0.25–0.89) | 3.82 × 10−2 | |
| Octadecanol | 19.08 | 0.56 | 3.98 × 10−2 | 0.64 (0.36–1.14) | 2.47 × 10−1 | |
| 2-Aminoethanethiol | 6.08 | 0.59 | 4.26 × 10−2 | 0.59 (0.32–1.06) | 9.38 × 10−2 | |
RT: retention time; fold change: ratio of metabolite levels between case and control groups; OR: odds ratio; P adj: P value adjusted for BMI, smoking, drinking, creatinine and C reactive protein, and postmenopausal status.