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Mechanisms involved in the anticancer activity of resveratrol. A number of cell processes are targeted by resveratrol, by upregulating (+) or downregulating (−) different pathways. ROS, reactive oxygen species; COX, cyclooxygenase; NFκB, nuclear factor κB; AP-1, activator protein 1; CDKs, cyclin-dependent kinases; BAX, B cell lymphoma-associated X; Bcl2, B cell lymphoma 2; ERs, estrogen receptors; HIF-1α, hypoxia-induced factor 1α; MMPs, matrix metalloproteinases.
