Table 2. Parameters used for threshold-tracking transcranial magnetic stimulation in patients with motor-neuron disease (MND), combined frontotemporal dementia (FTD) and MND, and FTD.
| TMS parameters | ALS | bvFTD | Controls | F test |
|---|---|---|---|---|
| Number of subjects | 15 | 13 | 16 | |
| RMT, % | 58.4±4.8 | 60.1±6.2 | 59.9±2.5 | n/s |
| MEP amplitude, mV | 2.4±0.4 | 2.7±0.4 | 3.7±0.6 | * |
| MEP amplitude/CMAP ratio, % | 41.3±8.0 | 32.2±4.9 | 21.7±3.7 | ** |
| MEP latency, ms | 25.5±0.8 | 28.2±0.4 | 20.0±0.5 | * |
| CMCT, ms | 9.1±0.5 | 6.4±0.7 | 5.6±0.5 | ** |
| Average SICI, % | 1.5±3.5 | 5.7±2.5 | 10.7±1.2 | * |
| SICI1, % | -0.1±1.9 | 2.9±2.5 | 11.7±1.7 | ** |
| SICI3, % | 4.1±4.5 | 9.5±3.1 | 15.5±1.9 | * |
| ICF, % | -5.6±2.5 | -1.6±0.7 | -1.0±1.3 | n/s |
| Maximum cortical silent period, ms | 177.3±10.7 | 198.0±5.1 | 259.1±70.1 | * |
Data are mean±SEM values. F values indicate significant differences between groups, *p<0.05, **p<0.01.
CMAP: compound motor action potential, CMCT: central motor conduction time, ICF: intracortical facilitation, MEP: motor evoked potential, n/s: not significant, RMT: resting motor threshold, SICI: short-interval intracortical inhibition, TMS: transcranial magnetic stimulation.