Table 2.
Multivariable‐adjusted associations of admission plasma tHcy with discharge outcomes from Stroke Unit in elderly patients with acute ischemic stroke
| Variables | Death during SU stay | Poor functional status | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | N | % | OR (95% CI) | P value | n | N | % | OR (95% CI) | P value | |
| 5 μmol/L increase in plasma tHcy | 34 | 644 | 5.3 | 1.02 (0.86–1.23) | 0.770 | 303 | 610 | 49.7 | 1.09 (0.99–1.21) | 0.072 |
| Hyperhomocysteinemia | ||||||||||
| Absent (<16 μmol/L) | 15 | 292 | 5.1 | 1.00 | 123 | 277 | 44.4 | 1.00 | ||
| Mild (16–29.9 μmol/L) | 14 | 274 | 5.1 | 0.63 (0.26–1.57) | 0.323 | 137 | 260 | 52.7 | 1.44 (0.93–2.24) | 0.105 |
| Moderate (≥30 μmol/L) | 5 | 78 | 6.4 | 1.04 (0.30–3.58) | 0.949 | 43 | 73 | 58.9 | 2.05 (1.05–4.01) | 0.035 |
n, number of cases; N, number of exposed; %, percentage of cases; SU, Stroke Unit; tHcy, total homocysteine. Odds Ratios (OR) and their 95% confidence intervals (95% CI) are from logistic models adjusted for age, sex, hypertension, diabetes mellitus, atrial fibrillation, hyperlipidemia, Charlson Comorbidity Index, admission National Institutes of Health Stroke Scale score, and admission C‐reactive protein, albumin, and estimated glomerular filtration rate. Analyses for poor functional status were limited to patients discharged alive.