Table 1.
Effect of probiotics (single or mixed culture) on treatment of Atopic Dermatitis (AD) in humans.
| Reference | Probiotics | Outcome |
|---|---|---|
| Majamaa and Isolauri, 1997 | Lactobacillus rhamnosus strain GG | SCORAD score improvement (P = 0.008) |
| Rosenfeldt et al., 2003 | L. rhamnosus + L. reuteri | Positive effect of probiotics seen in allergic subjects (P = 0.04) |
| Kirjavainen et al., 2003 | L. rhamnosus strain GG or L. GG | SCORAD decrease (P = 0.02) |
| Viljanen et al., 2005 | L. rhamnosus strain GG | Positive effect seen only in IgE-sensitized infants (P = 0.036) |
| Weston et al., 2005 | L. fermentum | SCORAD decrease (P = 0.03) |
| Passeron et al., 2006 | L. rhamnosus/synbiotics | No significant difference between synbiotics and placebo |
| Sistek et al., 2006 | L. rhamnosus + B. lactis | Positive effect seen only in food-sensitized children (P = 0.047) |
| Brouwer et al., 2006 | L. rhamnosus strain GG or L. rhamnosus | No significant difference between probiotics and placebo |
| Fölster-Holst et al., 2006 | L. rhamnosus strain GG | No significant difference between probiotics and placebo |
| Grüber et al., 2007 | L. rhamnosus strain GG | No significant difference between probiotics and placebo |
| Roessler et al., 2008 | L. paracasei + L. acidophilus + B. lactis | No significant effects of probiotics |
| Chernyshov, 2009 | L. rhamnosus 95%, L. helveticus 5% | SCORAD decrease in subjects not used topical steroids was shown only in probiotic group (P < 0.01) |
| Gerasimov et al., 2010 | L. acidophilus + B. lactis | SCORAD decrease (P = 0.001) |
| Woo et al., 2010 | L. sakei | SCORAD decrease (P = 0.008) |
| Cukrowska et al., 2010 | L. casei + L. paracasei | Clinical improvement seen mostly in children with IgE-dependent atopic eczema |
| Gobel et al., 2010 | L. acidophilus, or B. lactis/— | No beneficial effects observed |
| van der Aa et al., 2010 | B. breve/synbiotics | Improvement in IgE-sensitized infants (P = 0.04) |
| Yoshida et al., 2010 | B. breve | SCORAD decrease (P = 0.034) |
| Wu et al., 2011 | L. salivarius/ / synbiotics | SCORAD decrease at 8 week (P = 0.022) |
| Farid et al., 2011 | mixture/synbiotics | SCORAD decrease (P = 0.001) |
| Gore et al., 2012 | L. paracasei or Bifidobacterium | No significant difference between probiotics and placebo |
| Yesilova et al., 2012 | Bifidobacterium bifidum + L. acidophilus + L. casei + L. salivarius | SCORAD decrease (P = 0.0015) |
| Han et al., 2012 | L. plantarum | SCORAD decrease (P = 0.0015) |
| Iemoli et al., 2012 | L. salivarius; + B. breve | SCORAD decrease (P < 0.001) |
| Drago et al., 2011 | L. salivarius | SCORAD decrease (P < 0.001) |
| Niccoli et al., 2014 | L. salivarius LS01 | SCORAD and itch improvement |