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. 2016 Apr 12;10:39. doi: 10.3389/fnana.2016.00039

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Copyright © 2016 Voisin, Mnie-Filali, Giguère, Fortin, Vigneault, El Mestikawy, Descarries and Trudeau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The density of 5-HT immunoreactive terminals is reduced in the forebrain and caudal hippocampus of VGLUT3 KO mice. (A,B) Photomicrographs taken at 60× magnification, showing 5-HT immunoreactivity in the dorsal striatum (A) and dorsal hippocampus (B) of P60 VGLUT3 WT and KO mice. (C,D) Bar graphs illustrating the density of 5-HT (C) and SERT (D) immunoreactivity (mean gray value × signal area) within the dorsal striatum, lateral septum, dorsal and ventral hippocampus of P60 VGLUT3 WT and KO mice. Deletion of the VGLUT3 gene reduced the total density of 5-HT-positive varicosities in the dorsal striatum and dorsal hippocampus. Finally, the total density of SERT immunoreactivity was unchanged in the forebrain and dorsal hippocampus, but increased in the ventral hippocampus of VGLUT3 KO mice. Scale bar = 50 μm (60× magnification). *p < 0.05.