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. 2016 Apr 12;6:24357. doi: 10.1038/srep24357

Figure 2. Fundus photographs, fundus autofluorescence (FAF) imaging, fundus fluorescein angiography (FFA), and optical coherence tomography (OCT) findings in the two patients and the asymptomatic mother from family YZ.

Figure 2

(A,B) Fundus of patient YZ-II:4 indicates macular atrophy with loss of fovea reflex but no signs of peripheral involvement. (C,D) Oval hypofluorescent area in the maculae of both eyes is shown in the FAF of patient YZ-II:4. (E,F) FFA of patient YZ-II:4 notices speckled changes of increased fluorescence in the macular region of both eyes. (G,H) Similar to patient YZ-II:4, marked macular atrophy with fovea involved was also found in the fundus of both eyes of patient YZ-II:1. (I,J) The color fundus of the asymptomatic mother YZ-I:2. (K–P) OCT presentations of patients YZ-II:4 (K,L), YZ-II:1 (M,N), and their mother YZ-I:2 (O,P). The outer nucleus layer (ONL) and inner/outer segments (IS/OS) layers are vanished in the fovea and its surrounding maculae of patients YZ-II:4 and YZ-II:1 with no remarkable changes detected in the peripheral retina. Retinal pigment epithelium layer was significantly thinned in the maculae of patient YZ-II:1 but was slightly changed in patient YZ-II:4. OD = right eye; OS = left eye.