Table 2.
Effects of the two treatments on ambulatory blood pressure monitoring
| Losartan+barnidipine | Losartan+lercanidipine | ||||
|---|---|---|---|---|---|
| Baseline | End of study | Baseline | End of study | p for interaction between groups | |
| N | 75 | 72 | 76 | 71 | - |
| Sex (male/female) | 37/38 | 36/36 | 36/40 | 35/36 | ns |
| SBP (mmHg) | 150.8 ± 9.7 | 130.2 ± 5.6** | 152.5 ± 10.6 | 141.9 ± 6.5* | 0.041 |
| DBP (mmHg) | 96.6 ± 5.4 | 84.5 ± 5.7** | 96.7 ± 5.5 | 90.4 ± 5.9* | 0.039 |
| HR (beats/min) | 70.3 ± 7.7 | 70.1 ± 7.6 | 72.6 ± 8.1 | 72.2 ± 7.9 | ns |
| 24 h SBP (mmHg) | 142.5 ± 10.5 | 128.8 ± 7.3** | 143.2 ± 10.8 | 134.9 ± 8.5* | 0.042 |
| 24 h DBP (mmHg) | 94.7 ± 7.9 | 84.5 ± 6.1** | 94.3 ± 7.8 | 89 ± 7.1* | 0.045 |
| 24 h MBP (mmHg) | 118.2 ± 8.0 | 105.1 ± 6.1* | 116.3 ± 7.6 | 110.3 ± 7.1 | ns |
Data are means ± SD
SBP systolic blood pressure, DBP diastolic blood pressure, MBP mean blood pressure, HR heart rate
*p < 0.01 vs baseline; **p < 0.001 vs baseline