Fig. 3.
Comparison of whole-cell CaL current density in cerebral VSMCs isolated from CON, CON +100 mg/kg/day berberine, Diabetic, and diabetic +100 mg/kg/day berberine rats. Representative recording traces were used to show the whole-cell CaL currents (a) and the mean I–V curves were further expressed in terms of current densities (b) in different groups. Chronic administration of 100 mg/kg/day berberine markedly inhibited the increased CaL channel current density of cerebral VSMCs in diabetic rats. CON control rats, CON + berberine control rats administrated with berberine (100 mg/kg/day), Diabetic diabetic rats, diabetic + berberine: diabetic rats administrated with berberine (100 mg/kg/day). Values are mean ± SEM with the number of cells recorded in parentheses. *P < 0.05 vs. CON rats and # P < 0.05 vs. diabetic rats