Table 2.
GlycA relationships with disease activity, inflammatory, and adiposity measures
| GlycA | Fisher transformation | ||
|---|---|---|---|
| RA | Controls | P value | |
| Markers of disease activity and inflammation | |||
| Disability (HAQ-DI) | 0.28 | NA | NA |
| Pain (VAS) (mm) | 0.08 | 0.11 | 0.91 |
| Disease activity (DASESR-28) | 0.54 ‡ | NA | NA |
| ESR (mm/hour) | 0.71 ‡ | 0.24 | 0.02 |
| hsCRP (mg/l) | 0.73 ‡ | 0.32 † | 0.01 |
| IL-1β (pg/ml) | 0.19 | 0.08 | 0.62 |
| IL-6 (pg/ml) | 0.28 † | −0.14 | 0.05 |
| IL-8 (pg/ml) | −0.20 | −0.07 | 0.56 |
| IL-18 (pg/ml) | −0.14 | 0.41 † | 0.01 |
| TNFα (pg/ml) | −0.09 | −0.14 | 0.82 |
| Measures of adiposity and insulin resistance | |||
| BMI (kg/m2) | 0.16 | 0.38 † | 0.28 |
| Waist circumference (cm) | 0.12 | 0.38 † | 0.22 |
| Total abdominal adiposity (cm2) | 0.31 † | 0.36 † | 0.80 |
| Abdominal subcutaneous adiposity (cm2) | 0.26 | 0.34 † | 0.70 |
| Abdominal visceral adiposity (cm2) | 0.25 | 0.21 | 0.86 |
| Thigh subcutaneous adiposity (cm2) | 0.21 | 0.55 ‡ | 0.08 |
| Thigh intermuscular adiposity (cm2) | 0.06 | 0.18 | 0.60 |
| Thigh muscle density (Hu) | −0.33 † | −0.14 | 0.40 |
| Fasting insulin (mU/l) | 0.18 | 0.37 † | 0.38 |
| Fasting glucose (mg/dl) | 0.35 † | 0.16 | 0.36 |
| HOMA | 0.17 | 0.39 † | 0.30 |
| IS index (×10–5.min−1/(pmol/l)) | −0.26 | −0.34 † | 0.70 |
| Acute insulin response (pmol/l) | 0.05 | 0.48 † | 0.04 |
Data presented as Spearman correlation coefficients (r)
†0.005 < P <0.05, ‡ P ≤0.005
BMI body mass index, DAS ESR -28 Disease Activity Score with 28-joint count using the erythrocyte sedimentation rate, ESR erythrocyte sedimentation rate, HAQ-DI Health Assessment Questionnaire–Disability Index, HOMA homeostasis model assessment, hsCRP high-sensitivity C-reactive protein, IL interleukin, IS insulin sensitivity, RA rheumatoid arthritis, TNFα tumor necrosis factor alpha, VAS visual analog scale, NA not applicable
bold text represents significant associations