Table 1.
Summary of compounds, animals, and histological findings
| Number of animals | Liver histopathology | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Compound name | Abbreviation | Dose (mg · kg−1 · day−1) | Duration (days) | Control | Chemicals | Administration | Vehicle control | Fibrosis | Cellular infiltration | Necrosis | Proliferation | Ground glass appearance |
| Carbon tetrachloride | CCL4 | 100 | 28 | 5 | 5 | peroral | corn oil | Centrilobular, 5/5 (minimal) | Centrilobular | - | - | - |
| Lomustine | LS | 6 | 28 | 5 | 5 | peroral | 0.5 w/v% methylcellulose | Bile duct, 1/5 (minimal), 3/5 (mild) | Periportal | Midlobular | Bile duct, Kupffer cell | - |
| 2-Acetamidofluorene | AAF | 300 | 28 | 5 | 5 | peroral | 0.5 w/v% methylcellulose | negative | Periportal | - | Bile duct, Oval cell | - |
| N-Nitrosodiethylamine | DEN | 30 | 28 | 5 | 5 | peroral | 0.5 w/v% methylcellulose | negative | - | Centrilobular | Bile duct | - |
| Ethambutol | ETB | 1000 | 28 | 5 | 5 | peroral | 0.5 w/v% methylcellulose 0.5 w/v% | negative | - | Single cell | - | Centrilobular |
| Carbon tetrachloride | CCL4 | 100 | 3 | 5 | 5 | peroral | corn oil | negative | Centrilobular | - | - | - |
| Lomustine | LS | 6 | 3 | 5 | 5 | peroral | 0.5 w/v% methylcellulose 0.5 w/v% | negative | - | - | - | - |