Table 3.
GPx polymorphism and parameter stratification by CHD status
| Trait | Controls (203) | Cases (164) | P |
|---|---|---|---|
| Age (years) | 60.63 ± 12.27 | 62.98 ± 11.89 | 0.07 |
| Body mass index (kg/m2) | 24.73 ± 3.52 | 28.05 ± 3.17 | <10 −4 |
| Male, n (%) | 119 (58.62 %) | 97 (59.15 %) | 0.92 |
| Hypertension, n (%) | 13 (6.40 %) | 96 (58.54 %) | <10 −4 |
| Diabetes mellitus, n (%) | 10 (4.93 %) | 59 (35.98 %) | <10 −4 |
| Plasma glucose (mmol/l) | 4.33 ± 0.71 | 4.47 ± 2.91 | 0.51 |
| LDL cholesterol (mmol/l) | 2.54 ± 1.12 | 3.28 ± 1.13 | <10 −4 |
| HDL cholesterol (mmol/l) | 0.83 ± 0.37 | 0.82 ± 0.27 | 0.77 |
| Triglycerides (mmol/l) | 1.24 ± 0.64 | 1.31 ± 0.77 | 0.34 |
| Non enzymatic antioxidant parameters | |||
| Uric Acid (µmol/l) | 312.96 ± 92.00 | 335.82 ± 147.99 | 0.07 |
| Total bilirubin (µmol/l) | 17.04 ± 4.73 | 7.68 ± 4.81 | <10 −4 |
| Direct bilirubin (µmol/l) | 7.34 ± 3.21 | 2.36 ± 1.08 | <10 −4 |
| Albumin (g/l) | 41.74 ± 6.05 | 40.78 ± 4.18 | 0.09 |
| Iron (µmol/l) | 18.23 ± 4.94 | 16.38 ± 3.47 | <10 −4 |
| Enzymatic antioxidant parameters | |||
| GPx activity, (U/gHb) | 42.17 ± 13.99 | 40.20 ± 12.25 | 0.16 |
| TAS (mmol/l) | 1.68 ± 0.26 | 1.37 ± 0.25 | <10 −4 |
| GPx genotypes (%), n (CC/CT/TT) | 43.84/44.34/11.82 % | 55.49/37.80/6.71 % | 0.051 |
| 89/90/24 | 91/62/11 | 0.1 | |
| GPx genotypes (%), n (CC + CT/TT) | 88.18/11.82 % | 93.29/6.71 | |
| 179/24 | 153/11 | ||
*P < 0.05 was required for statistical significance