. Author manuscript; available in PMC: 2016 Oct 14.

Published in final edited form as: J Am Chem Soc. 2015 Oct 6;137(40):12796–12799. doi: 10.1021/jacs.5b09099

Table 2.

Pt-Catalyzed C–H Functionalization of N-Alkylpyrrolidines


substrate	major product	isolated yield	isolated selectivity (crude selectivity)^a
		25%^b	(β : α = >20 : 1)
		85%	γ : β = >20 : 1 (γ : β = 10 : 1)
		126%	δ : γ = 4 : 1 (δ : γ = 4 : 1)
		73%	ε : δ = 3 : 1 (ε : δ = 2 : 1)

Crude selectivity determined by ¹H NMR spectroscopic analysis prior to treatment with PivCl.

Yield determined by ¹H NMR spectroscopic analysis prior to treatment with PivCl.