Skip to main content
. Author manuscript; available in PMC: 2016 Apr 12.
Published in final edited form as: Adv Exp Med Biol. 2014;801:237–250. doi: 10.1007/978-1-4614-3209-8_31

Fig. 31.4.

Fig. 31.4

Inhibition of the proteasome alters the expression of inflammation-related genes. Confluent cultured ARPE-19 cells were incubated in fresh medium in the absence or presence of 10 µM MG132 for 8 h. Levels of mRNA for IL-6, IL-8, MCP-1, and CFH in the cells were determined by real-time quantitative RT-PCR using levels of mRNA for GAPDH as a reference. The relative levels of mRNA for these genes in control cells were arbitrarily designated as 1 and levels of mRNA for these genes in MG132-treated cells were expressed as fold of that in the control cells. The data are mean ± SD of the results from 4 samples in each group. * indicates p < 0.01 and ** indicates p < 0.001 as compared to the controls