Figure 1.

Wounds in diabetic rats at 14 and 17 days after injury.

(A) At 14 days after injury, wounds had healed: the surface was stripped and the wounds flat (a) in group A; the other three groups did not heal (b–d), although the control group did. (B) At 17 days after injury, groups A, B, and C had healed. a–d: Groups A–D. Group A: Injection of substance P + human amniotic membrane incubated with epidermal stem cells around and at the center of the wound; group B: injection of 250 μL PBS + human amniotic membrane incubated with epidermal stem cells around and at the center of the wound; group C: injection of substance P + human amniotic membrane without epidermal stem cells around and at the center of the wound; group D: injection of 250 μL PBS + human amniotic membrane without epidermal stem cells around and at the center of the wound. PBS: Phosphate buffered saline.