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. 2016 Mar;11(3):493–501. doi: 10.4103/1673-5374.179073

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of substance P combined with epidermal stem cells on types I and III collagen immunoreactivities in wounds of diabetic rats at 4, 7, 10 days after injury (immunohistochemical staining, × 400)

Type I collagen immunoreactivity gradually increased with time in each group. Type III collagen immunoreactivity was high in the early stage of injury, but gradually reduced with healing. Immunoreactivity is shown by a brown color. Group A: injection of substance P + human amniotic membrane incubated with epidermal stem cells around and at the center of the wound; group B: injection of 250 μL PBS + human amniotic membrane incubated with epidermal stem cells around and at the center of the wound; group C: injection of substance P + human amniotic membrane without epidermal stem cells around and at the center of the wound; group D: injection of 250 μL PBS+ human amniotic membrane without epidermal stem cells around and at the center of the wound. PBS: Phosphate buffered saline.