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. 2016 Apr 12;6:80. doi: 10.3389/fonc.2016.00080

Figure 1.

Figure 1

Safety margins applied at different clinical proton therapy facilities: (3.5% + 3-mm) at Loma Linda University Medical Center (LLUMC) (3.5% + 2-mm) at Universitäts Protonen Therapie Dresden (UPTD) (3.5% + 1-mm) at Massachusetts General Hospital (MGH) and (2.5% + 1.5-mm) at University of Florida Health Proton Therapy Institute (UFH). Range bonus refers to the margin added to the prescribed range to ensure full tumor coverage even in the case of an undershoot. These centers may apply bigger margins in specific treatment scenarios (62).