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No effect of allopurinol or oxypurinol on cell number, viability or ATP release. Cell number was measured after 7 or 14 days of treatment with 1 nM–10 µM allopurinol or oxypurinol; ATP release and viability were assessed in mature osteoblasts. At all concentrations tested, (A-B) allopurinol and (C-D) oxypurinol had no effect on cell number, controlled ATP release (solid bars, primary y axis) or viability (lines, secondary y axis). Values are means±SEM (n=6–12).
