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. 2016 Mar 15;342(2):166–174. doi: 10.1016/j.yexcr.2016.03.004

Fig. 5.

Fig. 5

Allopurinol and oxypurinol influence the expression of key osteoblast genes. The effect of allopurinol and oxypurinol (0.1 μM) on the expression of collagen type I (Col1α1), osteocalcin (Ocn), TNAP, XO and ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) was in investigated in differentiating and mature osteoblasts. (A) Allopurinol decreased Npp1 expression ~5-fold in differentiating osteoblasts. (B) In mature osteoblasts, allopurinol increased TNAP and Ocn expression 2-fold and 5-fold, respectively. (C and D) Oxypurinol reduced Npp1 expression 5-fold in differentiating and mature osteoblasts. Levels of TNAP and Ocn expression were increased 2-fold and 5-fold, respectively in mature osteoblasts. Values are means±SEM (n=4), *=p<0.05.