Table 1.
HIV RT resistance mutations most commonly associated with the presence of 65K and/or 66K silent mutations. Data is pooled from available clade B RT sequences in the BC Centre for Excellence database. Data is sorted by p-value for illustration.
| RT Codon | Number With Silent Mutation (%) | Number Without Silent Mutation (%) | p-Value |
|---|---|---|---|
| 67 | 1755 (69.6) | 767 (30.4) | 2.6 × 10−153 |
| 219 | 1182 (64.6) | 649 (35.5) | 5.5 × 10−86 |
| 70 | 921 (51.4) | 871 (48.6) | 9.4 × 10−48 |
| 215 | 1691 (42.5) | 2291 (57.5) | 2.0 × 10−45 |
| 41 | 1408 (43.2) | 1851 (56.8) | 3.0 × 10−35 |
| 65 | 33 (15.1) | 185 (84.9) | 1.8 × 10−29 |
| 184 | 1973 (33.2) | 3969 (66.8) | 1.8 × 10−27 |
| 210 | 1054 (45.5) | 1262 (54.5) | 5.3 × 10−26 |