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Overexpression of EZH2 decreases expression levels of DNA damage repair and cell cycle arrest-related genes. Overexpression of EZH2 was achieved by adenoviral transduction approach in HuLM cells. The expression of EZH2 (A), RAD51 (B), BRCA1 (C), and p21 (D) was determined by real-time PCR after infection of HuLM cells with Ad-EZH2 (20 pfu) and Ad-GFP (20 pfu) for 3 days. *P < 0.05 compared with the control.
