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. 2016 Mar 8;37(5):1263–1273. doi: 10.3892/ijmm.2016.2519

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Representative fluorescence images showing the double-labelling of laminin-5 and integrin-β4 in normal, wound edge and hypertrophic scar tissue. (A–I) The distribution of laminin-5 and integrin-β4 was detected in the basement membrane (BM) area in both (A–C) normal and (D–F) wound edge skin tissues. (G–I) The formation of BM-like structures in the absence of laminin-5 and integrin-β4 expression was observed in the epidermis of hypertrophic scar tissues. White dotted lines denote the basement membrane, which separated the epidermis and dermis. All scale bars represent 25 μm.