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. 2016 Mar 28;37(5):1221–1228. doi: 10.3892/ijmm.2016.2541

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Copyright: © Seo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of E. japonicum on the expression of Th1-related cytokines in mouse lung tissue. (A) Representative images of interferon-γ (IFN-γ)⁺ cells. (B) Representative images of interleukin (IL)-12p35⁺ cells. (C) Representative images of IL-12p40⁺ cells. Immunopositive cells were counted in 5 randomly selected, non-overlapping fields (magnification, ×200) from 3 separately immunostained lung sections per animal. Treatment groups: panel a, control (CON); panel b, ovalbumin (OVA); panel c, dexamethasone (DEX); panel d, 60 mg/kg/day E. japonicum (E.j); panel e, 600 mg/kg/day E.j. (D) Quantitative analysis of positively-stained cells.^*p<0.05 vs. CON; ^**p<0.001 vs. CON; ^$p<0.05 vs. OVA; ^$$p<0.001 vs. OVA; ^#p<0.05 vs. DEX; ^##p<0.001 vs. DEX; ^sp<0.05 vs. 60 mg/kg/day E.j; ^ssp<0.001 vs. 60 mg/kg/day E.j.