Skip to main content
. 2016 Apr 12;12(4):e1005984. doi: 10.1371/journal.pgen.1005984

Fig 5. Proliferation and cell cycle regulator effects in Notch pathway perturbations.

Fig 5

(A-D) Proliferation (pH3+ cells) is reduced in embryos misexpressing m8CK2 and m8CK2, Antp, cas, when compared to control (one thoracic segment). (E-F) Quantification of NB and daughter proliferation, in T2-T3 (E) and A1-A2 (F) (* p≤0.05, ** p≤0.01, *** p≤0.001; +/-SD; Student’s two-tailed T-test; n≥18 segments). (G-L) Expression of CycE, Dap and Stg; one thoracic segment; Dpn was used to identify NBs. (G-H) Triple misexpression of m8CK2, cas and Antp reduces CycE expression. (I-L) Misexpression of m8CK2 reduces Dap and Stg expression. (M-N) Expression of CycE, E2f and Dacapo (Dap) in the NB5-6T neuroblast, at St13-14 (* p≤0.05, ** p≤0.01, *** p≤0.001; +/-SD; Student’s two-tailed T-test; n≥12 NBs).