Table 4. Longitudinal studies of NAFLD and NASH using Paired Biopsies.
| Author (year) | N | Follow-up (years) | Fibrosis Progressed (N) | Fibrosis Regressed (N) | Factors |
|---|---|---|---|---|---|
| Lee (1989)61 | 13 | 3.5 | 5 | 0 | |
| Powell (1990)36 | 13 | 3.5 | 4 | 1 | |
| Bacon (1994)62 | 2 | 5.5 | 1 | 0 | |
| Teli (1995)15 | 12 | 1 | 0 | ||
| Ratziu (2000)63 | 14 | 5.2 | 2 | 4 | |
| Evans (2002)64 | 7 | 8.2 | 4 | 0 | |
| Harrison (2003)65 | 22 | 5.4 | 9 | 4 | AST |
| Fassio (2004)66 | 22 | 5.3 | 7 | 4 | Obesity, BMI |
| Adams (2005)67 | 103 | 3.2 | 38 | 30 | DM, BMI, Fibrosis stage |
| Hui (2005)68 | 17 | 6.1 | 9 | 0 | None |
| Ekstedt (2006)69 | 68 | 13.8 | 29 | 11 | None |
| Caldwell (2009)70 | 7 | 6 | 7 | ||
| Feldstein (2009)71 | 5 | 3.4 | 4 | 0 | |
| Sorrentino (2010)72 | 132 | 6.4 | 45 | 11 | Fibronectin, HTN, HOMA-IR |
| Wong (2010)73 | 52 | 3 | 14 | 13 | Increased BMI and Waist circumference |
| Hamaguchi (2010)74 | 39 | 2.4 | 11 | 12 | Hemoglobin A1c |
| Pais (2011)75 | 6 | 5 | 6 | ||
| Pais (2013)59 | 70 | 3.7 | 20 | 20 | Age, DM |
| McPherson (2015)58 | 108 | 6.6 | 45 | 20 | DM at follow-up |
| Total | 712 | 37% | 18% |
Abbreviations: AST – aspartate aminotransferase; BMI – body mass index; HTN – hypertension; DM – diabetes mellitus; HOMA-IR – Homeostatic model assessment of insulin resistance