. Author manuscript; available in PMC: 2016 Apr 12.

Published in final edited form as: J Gastroenterol Hepatol. 2015 Oct;30(10):1543–1551. doi: 10.1111/jgh.12936

Table 2.

Frequency of CD3⁺ T cells, colonic T_reg cells and average values of plasma cytokines levels in the study groups

	TN group (n = 20)	NR group (n = 20)	SVR group (n = 20)	Control group (n = 10)
CD3 T-cell number/HPF
Range	2–27	3–30	3–26	8–16
(Mean ± SD)	13 ± 8.5	14.4 ± 8.3	11.0 ± 5.8	12.2 (± 2.7)
Colonic T_reg number
Range	0–13	1–10	0–2	0–2
(Mean ± SD)	3.5 ± 3.5	3.6 ± 2.6	0.3 ± 0.6	0.5 ± 0.7
% Colonic T_reg frequency (mean ± SD)	30.62 ± 22.13	25 ± 11.6	4.18 ± 8.6	3.9 ± 5.1
Plasma cytokine levels,^† pg/mL (mean ± SD)
IL-2	2.61 ± 1.160	5.18 ± 4.35	3.46 ± 0.67	5.78 ± 7.4
1L-4	185 ± 61.69	143 ± 116.15	47 ± 28	34.50 ± 62.61
IL-10	18.98 ± 8.32	12.80 ± 9.29	7.75 ± 5.83	5.66 ± 5.746
TNF-α	23 ± 11	22.62 ± 9.38	15.21 ± 3.39	12.66 ± 4.82
IFN-γ	18.42 ± 26.37	17.17 ± 32.11	7.9115 ± 7.79	9.416 ± 2.23

^†

The lower level of detection (LLD) for IL-2, TNF-α, and IFN-γ is (LLDs = 0.64 pg/mL) while the lower level of detection (LLD) for IL-4 and IL-10 is (LLDs = 3.2 pg/mL). Additionally, we did not consider analysis of the data if any of the cytokines levels in > 50% of the samples were below detection limit (BDL).

HPF, high-power field; IFN-γ, γ-interferon; IL, interleukin; NR, non-responders; SVR, sustained virologic response; TN, treatment naïve; TNF-α, tumor necrosis factor-α; T_reg, regulatory T.