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. Author manuscript; available in PMC: 2016 Apr 12.
Published in final edited form as: J Gastroenterol Hepatol. 2015 Oct;30(10):1543–1551. doi: 10.1111/jgh.12936

Table 4.

Correlations between cytokines levels and HCV viral load, frequency of colonic Treg cells, and liver pathology

Correlation with HCV viral load Correlation with % Treg frequency Correlation with liver biopsy inflammatory score Correlation with liver biopsy fibrosis stage
r P-value 95%CI r P-value 95%CI r P-value 95% CI r P-value 95%CI
IL-2 0.15 0.53 −0.32 to 0.57 −0.14 0.58 −0.56 to 0.34 0.23 0.33 −0.23 to 0.61 0.29 0.2 −0.23 to 0.61
IL-4 0.37 0.02* 0.05 to 0.62 0.34 0.04* 0.02 to 0.6 −0.65 0.04* −0.91 to −0.04 −0.67 0.03* −0.91 to −0.07
IL-10 0.51 < 0.0001* 0.28 to 0.68 0.28 0.02* 0.04 to 0.49 −0.66 0.03* −0.91 to −0.06 −0.74 0.01* −0.93 to −0.19
TNF-α 0.08 0.52 −0.16 to 0.31 0.21 0.08 −0.04 to 0.43 0.04 0.85 −0.41 to 0.48 −0.001 0.99 −0.44 to 0.44
IFN-γ 0.09 0.48 −0.16 to 0.33 0.11 0.39 −0.14 to 0.35 0.10 0.67 −0.36 to 0.52 0.14 0.55 −0.32 to 0.55
*

Significant difference.

CI, confidence interval; HCV, hepatitis C virus; IFN-γ, γ-interferon; IL, interleukin; NR, non-responders; SVR, sustained virologic response; TN, treatment naïve; TNF-α, tumor necrosis factor-α; Treg, regulatory T.