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. 2016 Apr 12;11(4):e0153418. doi: 10.1371/journal.pone.0153418

Fig 3. SOCS2 overexpression increased numbers of proliferative cells in injured cortex compared to WT after mild but not moderately severe TBI.

Fig 3

The perilesional cortex of SOCS2Tg and WT animals was analysed 35d post TBI or sham surgery for presence of EdU+ cells. In injured mice there was a significant increase in EdU+ cells in the ipsilateral cortex and after mild TBI (A) this increase was 2 fold greater in SOCS2Tg mice compared to WT. While there was an injury induced increase in proliferative cells after moderately severe TBI (B), there was no effect of SOCS2 overexpression There was also no significant effect of SOCS2 overexpression on proliferative cell numbers at 7d post moderately severe TBI (C). Results show mean ± SEM; n = 5–8 mice/group **P<0.01, ***P<0.001, **** P<0.0001 (ANOVA with Bonferroni post hoc test).