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. 2016 Apr 12;11(4):e0153418. doi: 10.1371/journal.pone.0153418

Fig 7. SOCS2 overexpression had no effect on generation of oligodendrocytes.

Fig 7

The perilesional cortex of SOCS2Tg and WT mice was analysed at 7d and 35d post TBI or sham surgery for density of EdU+Olig2+ cells. Representative images of WT (A) and SOCS2Tg (B) cortex are shown after moderately severe injury are shown. Scale bar A,B = 100 μm. The merged panels are the EdU and Olig2 panels combined. Examples of co-labelled cells in injured cortex are indicated by arrows in panels A and B. In the ipsilateral cortex of SOCS2Tg and WT injured animals there was an overall injury-induced increase in EdU+Olig2+ cell density at 35d post mild TBI (C) which was further enhanced after moderately severe TBI (D) but with no effect of genotype. Further, there was no effect of genotype on EdU+Olig2+ (E) or Olig2+ (F) cell density in injured cortex at 7d post moderately severe TBI. Results show mean ± SEM; n = 3–8 mice/group.