Table 3. Association of coagulopathy and acute liver failure with hyperammonemia.

Laboratory parameters	INR	Quick (%)	aPTTa (sec.)	Clotting factors (%)		Albumin (g/L)	Ammonia (μmol/L)
				Vb	VIIb
Normal Range	<1.2	>70	<40	>70	>60	34–42	12–48
At diagnosis	2.3	30	42	43	14	30	498
In remission state	0.9	>110	n.d.	131	115	33	40
At metabolic crisis	4.2	16	55	24	2	28	354

Table 3 illustrates two episodes of acute liver failure, which occurred within 2 months in patient 20. While INR markedly increased and levels of factor VII (plasma half-life: 5 hours) and factor V (plasma half-life: 15 hours) decreased during hyperammonemia, all laboratory parameters normalized between events. Albumin (plasma half-life 20 days) remained in the (lower) normal range during hyperammonemic episodes.

^aaPTT, activated partial thromboplastin time

^bClotting factors V and VII.