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A proposed model of the exosome-mediated miR-21 transfer in the RIBE. In irradiated cells, the expression of miR-21 is up-regulated and as a response, miR-21 sorting to exosomes is motivated. The exosomes are secreted out from the irradiated cells, diffused into extracellular medium, taken up by non-irradiated cells, and the miR-21 inside the exosomes are released into bystander cells to induce bystander effects.
